Investigator

Mohit Kumar Jolly

Associate Professor · Indian Institute of Science Bangalore, Bioengineering

MKJMohit Kumar Jolly
Papers(2)
Exploring the role of…A Multistep Tumor Gro…
Collaborators(3)
Samuel OliverAyalur Raghu Subbalak…Deyarina Gonzalez
Institutions(2)
Indian Institute Of S…Swansea University

Papers

A Multistep Tumor Growth Model of High-Grade Serous Ovarian Carcinoma Identifies Hypoxia-Associated Signatures

High-grade serous ovarian carcinoma (HGSC) is associated with late-stage disease presentation and poor prognosis, with a limited understanding of early transformation events. Our study analyzes HGSC tumor progression and organ-specific metastatic dissemination to identify hypoxia-associated molecular, cellular, and histological alterations. Clinical characteristics of the HGSC were replicated in orthotopic xenografts, which involve metastatic dissemination and the prevalence of group B tumors (volume: >0.0625 ≤ 0.5 cm<sup>3</sup>). Enhanced hyaluronic acid (HA) deposition, expanded tumor vasculature, and increased necrosis contributed to the remodeling of tumor tissue architecture. The proliferative potential of tumor cells and the ability to form glands were also altered during tumor growth. Flow cytometry and label chase-based molecular profiling across the tumor regenerative hierarchy identified the hypoxia-vasculogenic niche and the hybrid epithelial-mesenchymal tumor-cell state as determinants of self-renewal capabilities of progenitors and cancer stem cells. A regulatory network and mathematical model based on tumor histology and molecular signatures predicted hypoxia-inducible factor 1-alpha (HIF1A) as a central node connecting HA synthesis, epithelial-mesenchymal transition, metabolic, vasculogenic, inflammatory, and necrotic pathways in HGSC tumors. Thus, our findings provide a temporal resolution of hypoxia-associated events that sculpt HGSC tumor growth; an in-depth understanding of it may aid in the early detection and treatment of HGSC.

264Works
2Papers
3Collaborators
NeoplasmsCell Line, TumorTumor MicroenvironmentBreast NeoplasmsDisease ProgressionNeoplasm MetastasisNeoplasm InvasivenessTuberculosis

Positions

2023–

Associate Professor

Indian Institute of Science Bangalore · Bioengineering

2018–

Assistant Professor

Indian Institute of Science · Centre for BioSystems Science and Engineering

2016–

Postdoctoral fellow

Rice University · Center for Theoretical Biological Physics

Education

2016

PhD

Rice University · Bioengineering

2012

M Tech (Master of Technology)

Indian Institute of Technology Kanpur · Biological Sciences and Bioengineering

2010

B Tech (Bachelor of Technology)

Indian Institute of Technology Kanpur · Biological Sciences and Bioengineering

Country

IN