Investigator

Ming-Yu Yang

Assistant Professor · Chang Gung University College of Medicine, Graduate Institute of Clinical Medical Sciences

MYMing-Yu Yang
Papers(2)
Molecular Interplay B…How Progesterone Rece…
Collaborators(4)
Hung-Chun FuChao-Cheng HuangChen-Hsuan WuHao Lin
Institutions(3)
Chang Gung UniversityChang Gung Memorial H…Sichuan University

Papers

How Progesterone Receptor Expression Impacts Platinum Sensitivity in Ovarian Clear Cell Carcinoma: Insights from Clinical and Experimental Perspectives

Ovarian clear cell carcinoma (OCCC) is often considered a relatively platinum-resistant malignancy. The aim of this study was to explore the influence of progesterone receptor (PR) expression levels on platinum sensitivity and survival outcomes in people with OCCC. A retrospective analysis was conducted with 80 people with OCCC who underwent surgery followed by adjuvant chemotherapy. PR expression was assessed via immunohistochemical (IHC) staining and quantified using the H score. The platinum sensitivity and survival outcomes of patients with weak and strong PR expression were compared. Additionally, cisplatin viability and migration experiments were conducted with OCCC cell lines (ES-2 and TOV-21G) with varying PR isoform expressions. Among the 80 patients, 62 were classified as having platinum-sensitive disease, while 18 had platinum-resistant disease. The mean total PR H- score of platinum-sensitive tumors was significantly higher than that of platinum-resistant tumors (p = 0.002). Although no significant differences in progression-free and overall survival were observed between patients with high and low PR expression, those with high PR expression tended to have longer survival. While PR protein was only weakly detectable in ES-2 and TOV-21G cells, a transfection of the PR-A or PR-B gene resulted in a strong expression of PR-A or PR-B, which led to significantly reduced proliferation and migration in ES-2 and TOV-21G cells. Furthermore, overexpression of PR-A or PR-B enhanced cisplatin cytotoxicity in these cell lines. In conclusion, strong PR expression was associated with improved platinum sensitivity and survival outcomes, consistent with our experimental findings. The potential of PR as a tumor sensitizer to cisplatin in OCCC warrants further investigation.

35Works
2Papers
4Collaborators
Ovarian NeoplasmsMeniere DiseaseCell Line, TumorApoptosisMigraine DisordersSleep Wake DisordersLaryngeal Diseases

Positions

2008–

Assistant Professor

Chang Gung University College of Medicine · Graduate Institute of Clinical Medical Sciences

2008–

Assistant Professor

Chang Gung University College of Medicine · Graduate Institute of Clinical Medical Sciences

2008–

Assistant Professor

Chang Gung University College of Medicine · Graduate Institute of Clinical Medical Sciences

Education

2004

Ph.D.

Kaohsiung Medical University College of Medicine · Graduate Institute of Medical Sciences

1995

M.S.

University of Tennessee · Graduate Institute of Biomedical Sciences

Keywords
生物技術分子生物學基礎醫學BiotechnologyMolecular biologyBasic medicine