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Investigator

Michela Tinelli

London School of Economics and Political Science

About

Research Interests

Papers

Treatment methods for cervical intraepithelial neoplasia in England: A cost‐effectiveness analysis

AbstractObjectiveTo compare the cost‐effectiveness of different treatments for cervical intraepithelial neoplasia (CIN).DesignA cost‐effectiveness analysis based on data available in the literature and expert opinion.SettingEngland.PopulationWomen treated for CIN.MethodsWe developed a decision‐analytic model to simulate the clinical course of 1000 women who received local treatment for CIN and were followed up for 10 years after treatment. In the model we considered surgical complications as well as oncological and reproductive outcomes over the 10‐year period. The costs calculated were those incurred by the National Health Service (NHS) of England.Main outcome measuresCost per one CIN2+ recurrence averted (oncological outcome); cost per one preterm birth averted (reproductive outcome); overall cost per one adverse oncological or reproductive outcome averted.ResultsFor young women of reproductive age, large loop excision of the transformation zone (LLETZ) was the most cost‐effective treatment overall at all willingness‐to‐pay thresholds. For postmenopausal women, LLETZ remained the most cost‐effective treatment up to a threshold of £31,500, but laser conisation became the most cost‐effective treatment above that threshold.ConclusionsLLETZ is the most cost‐effective treatment for both younger and older women. However, for older women, more radical excision with laser conisation could also be considered if the NHS is willing to spend more than £31,500 to avert one CIN2+ recurrence.

530Works

1Papers

3Collaborators

Autistic DisorderHeadache DisordersNeoplasm Recurrence, LocalUterine Cervical Neoplasms

Positions

Researcher

London School of Economics and Political Science

2024–

Associate Professorial Research Fellow

London School of Economics and Political Science · Care Policy Evaluation Centre

2015–

Assistant Professorial Research Fellow

London School of Economics and Political Science · Care Policy Evaluation Centre

2014–

Research Associate

London School of Economics and Political Science · LSE Enterprise

2010–

Part-time Researcher/ Research Fellow

London School of Economics and Political Science · LSE Health and Social Care

2008–

Part-time ESRC/MRC Interdisciplinary Research Fellow

University of Aberdeen · Health Economics Research Unit and Centre for Academic Primary Care

2008–

Part-time Research Fellow – Health Economist

National Collaborating Centre for Children’s and Women’s Health (NICE Clinical guideline :CG99 Published: 26 May 2010)

2008–

Research Analyst

Queen Mary University of London · Centre of Primary Care and Public Health

2007–

Researcher

Maternity leave

2004–

ESRC/MRC and college funded PhD student - Research Assistant

University of Aberdeen · Health Economics Research Unit and Centre for Academic Primary Care, University of Aberdeen

2005–

Part-time pre-registration pharmacist

Charles Michie Pharmacy

2003–

Research Assistant

University of Aberdeen · Centre for Academic Primary Care/Health Economic Research Unit

1999–

Research Fellow

University of Milan · Centre of Pharmacoeconomics

1998–

Part-time pre-registration pharmacist

Geminiani Pharmacy

Education

2023

Post graduate course: Understanding and Predicting Choice Behaviour in Health: Preference Elicitation and Analysis

University of Oxford · Health Economics Research Centre

2009

Post graduate course: Advanced Methods of Cost-Effectiveness Analysis

University of Oxford · Health Economics Research Centre

2007

PhD in Health Economics and Primary Care

University of Aberdeen · Health Economics Research Unit; Academic Centre of Primary Care

2006

Post graduate course: Discrete choice modelling

University College London · UCL Economics Department

2006

Post graduate course: Marie Curie Training Programme in Applied Health Economics

University of York

2006

Post graduate course: Essex Summer School in Social Science Data Analysis

University of Essex

2003

MSc(Hons) in Public Health and Health Services Research (Health Economics)

University of Aberdeen · Health Economics Research Unit and Academic Centre of Primary Care

2002

MSc(Hons) in Pharmacoeconomics

University of Milan · Centre of Pharmacoeconomics

2001

Post graduate course: Harvard Mediterranean School of Epidemiology and Statistical Methods in Biomedical Research

Harvard University · School of Public Health

1999

Pharm D (summa cum laude; the highest grade) in Pharmaceutical Chemistry (Biotechnology)

University of Milan · Department of Pharmacology

Country

Keywords

Health and care economicsChoice modelling / discrete choice experimentsParticipatory researchSocial care researchCost–consequence analysisEconomic evaluationHealth and care inequalitiesHealth and social care integrationImpact evaluationBusiness caseMarginalised / vulnerable populationsSelf-neglect / hoardingMultiple exclusion homelessnessDrug and alcohol misuseReal-time service evaluationData visualisationEvidence synthesisPredictive analyticsCapacity buildingKnowledge mobilisationCo-developmentStakeholder engagement

Links & IDs

0000-0002-8816-4389