Investigator

Mayra Valencia Zapata

Docente · Universidad Industrial de Santander, Escuela de Ingeniería Metalúrgica y de Materiales

MVZMayra Valencia Za…
Papers(1)
Evaluation of the Ant…
Collaborators(5)
Carlos Grande-TovarCarlos Valencia-LlanoDaniel InsuastyJorge CastroJose Mina Hernández
Institutions(4)
Universidad Del ValleUniversidad del Atlán…Universidad del ValleUniversidad del Norte

Papers

Evaluation of the Antibacterial, Anti-Cervical Cancer Capacity, and Biocompatibility of Different Graphene Oxides

Cancer stands as one of the deadliest diseases in human history, marked by an inferior prognosis. While traditional therapeutic methods like surgery, chemotherapy, and radiation have demonstrated success in inhibiting tumor cell growth, their side effects often limit overall benefits and patient acceptance. In this regard, three different graphene oxides (GO) with variations in their degrees of oxidation were studied chemically and tissue-wise. The accuracy of the synthesis of the different GO was verified by robust techniques using X-ray photoelectron spectroscopy (XPS), as well as conventional techniques such as infrared spectroscopy (FTIR), RAMAN spectroscopy, and X-ray diffraction (XRD). The presence of oxygenated groups was of great importance. It affected the physicochemical properties of each of the different graphene oxides demonstrated in the presence of new vibrational modes related to the formation of new bonds promoted by the graphitization of the materials. The toxicity analysis in the Hep-2 cell line of graphene oxide formulations at 250 µg/mL on the viability and proliferation of these tumor cells showed low activity. GO formulations did not show high antibacterial activity against Staphylococcus aureus and Escherichia coli strains. However, the different graphene oxides showed biocompatibility in the subdermal implantation model for 30, 60, and 90 days in the biomodels. This allowed healing by restoring hair and tissue architecture without triggering an aggressive immune response.

24Works
1Papers
5Collaborators
Uterine Cervical NeoplasmsOsteoarthritis

Positions

2024–

Docente

Universidad Industrial de Santander · Escuela de Ingeniería Metalúrgica y de Materiales

2019–

Professor

Universidad del Valle · Faculty of Health

2009–

Professor

Universidad de San Buenaventura - Cali · Faculty of Engineering

2014–

Professor

Pontificia Universidad Javeriana - Cali · Department of Civil and Industrial Engineering

Education

2021

Ph. D in Engineering

Universidad del Valle · Materials Engineering School

2010

Magister in Engineering

Universidad del Valle · Materials Engineering School

2006

Materials Engineering

Universidad del Valle · Faculty of Engineering