Investigator

Maria do Desterro Soares Brandão Nascimento

Coordenador do Curso de Medicina · Universidade Federal do Maranhão, Curso de Medicina

MDDMaria do Desterro…
Papers(1)
HPV 18 variants in wo…
Collaborators(1)
Ana Paula Almeida Cun…
Institutions(1)
Universidade Federal …

Papers

HPV 18 variants in women with cervical cancer in Northeast Brazil

Human Papillomavirus (HPV) is the main etiological factor for the development of cervical cancer. HPV 18 is the second most frequent type, accounting for up to 65% of all cases. HPV intratypic variation may influence the potential for progression to invasive cancer. The aim of this study was to evaluate the prevalence of human papillomavirus 18 intratypic variants in cervical cancer samples from women in the state of Maranhão, Brazil. The study included 118 women over 18 years of age with a diagnosis of cervical cancer. Tumor fragments were collected and subjected to DNA extraction and Polymerase Chain Reaction (PCR) for HPV detection using the PGMY09/11 and GP+5/6 primers. Positive samples were submitted to automated sequencing for viral genotyping. To determine the HPV 18 lineages, positive samples were submitted to PCR, using specific primers to amplify the LCR and E6 regions of HPV 18 virus. HPV was present in 88 women (73.3%). Of those, 48 (54%) were HPV 16, the most prevalent, followed by 12 (13.6%) HPV 18. Histologically, squamous cell carcinoma was predominant (79.1%). Among the HPV 18 variants identified, 10 (80%) belonged to lineage A, and sublineages A1, A2, A3, and A4. Two (29%) HPV 18 B variant was also detected, with the sublineages B1 and B2. In this study, the C variant was not found. There was no statistically significant association between the HPV 18 lineages found and sociodemographic and lifestyle variables (p > 0.05). A higher frequency of HPV 16 and 18 were found in women with cervical cancer in the state of Maranhão, Brazil, with a high prevalence of the lineage A among women with HPV 18.

24Works
1Papers
1Collaborators
Hepatitis B, ChronicBreast NeoplasmsHepatitis B virusHepatitis B Surface AntigensHepatitis BHepatitis B AntibodiesHepatitis B VaccinesCarcinoma, Hepatocellular

Positions

2022–

Coordenador do Curso de Medicina

Universidade Federal do Maranhão · Curso de Medicina

2021–

Professor Adjunto do Curso de Medicina

Universidade Federal do Maranhão · Curso de Medicina

2020–

Médico

Hospital Universitário da Universidade Federal do Maranhão · Unidade de Terapia Intensiva Adulto

Education

2022

Universidade Estadual de Campinas · Faculdade de Ciências M´édicas

2017

Universidade Federal do Maranhão