Investigator

Luís Felipe Leite Martins

Statistician and Epidemiologist · Brazilian National Cancer Institute, Division of Cancer Surveillance and Situation Analysis

Research Interests

LFLLuís Felipe Leite…
Papers(2)
Desigualdades sociais…Human Papillomavirus …
Collaborators(10)
Marianna de Camargo C…Miguel Angelo Martins…Nayara Priscila Danta…Neilane Bertoni dos R…Rodrigo Alves PintoShayany Pinto FelixAriani Impieri SouzaDyego Leandro Bezerra…Janete Lima de CastroJoão Paulo Castello B…
Institutions(6)
Ministrio Da SadeInstituto Nacional De…Universidade De Perna…Instituto De Medicina…Universidade Federal …Universidade Federal …

Papers

Human Papillomavirus 16 Lineage D is Associated with High Risk of Cervical Cancer in the Brazilian Northeast Region

Abstract Objective Similar to Human Papillomavirus (HPV) genotypes, different lineages of a genotype also have different carcinogenic capabilities. Studies have shown that specific genotype lineages of oncogenic HPV are associated with variable risks for the development of cervical intraepithelial neoplasia (CIN2/CIN3) and cervical cancer. The present study aimed to analyze the genetic diversity of the HPV16 genotype in women with CIN2/CIN3 and cervical cancer, from the northeast region of Brazil. Methods A cross-sectional multicenter study was conducted in the northeast region of Brazil, from 2014 to 2016. This study included 196 cases of HPV16 variants (59 and 137 cases of CIN2/CIN3 and cervical cancer, respectively). The difference of proportion test was used to compare patients with CIN2/CIN3 and cervical cancer, based on the prevalent HPV16 lineage (p < 0.05). Results According to the histopathological diagnosis, the percentage of lineage frequencies revealed a marginal difference in the prevalence of lineage A in CIN2/CIN3, compared with that in cervical cancer (p = 0.053). For lineage D, the proportion was higher in cancer cases (32.8%), than in CIN2/CIN3 cases (16.9%), with p = 0.023. Conclusion HPV16 lineage A was the most frequent lineage in both CIN2/CIN3 and cervical cancer samples, while lineage D was predominant in cervical cancer, suggesting a possible association between HPV16 lineage D and cervical cancer.

30Works
2Papers
13Collaborators
Neoplasm StagingColorectal NeoplasmsPapillomavirus Infections

Positions

1999–

Statistician and Epidemiologist

Brazilian National Cancer Institute · Division of Cancer Surveillance and Situation Analysis

Education

2000

Bachelor in Statistics

National School of Statistical Sciences (ENCE/IBGE)

Country

BR