Long Nguyen

Treatment Outcome and Prognosis Factors of FIGO 2018 Stage III Cervical Cancer Patients Treated with Definitive Concurrent Chemoradiation in Vietnam

This study aimed to analyze the treatment outcome and toxicities, along with prognosis factors of patients with FIGO 2018 stage III cervical cancer treated with definitive concurrent chemoradiation. A total of 83 stage III cervical cancer patients with good performance status (ECOG PS 0, 1) were treated with three-dimensional conformal radiation therapy (3D-CRT) combined with chemotherapy (weekly cisplatin), followed by high-dose-rate (HDR) brachytherapy between January 2017 and March 2019 at Vietnam National Cancer hospital. Treatment outcomes and prognosis factors were assessed along with acute and late toxicities. The 3-year DFS was 67.8% and 3-year OS was 80.3%. On multivariate analyses, short axis of pelvic lymph node diameter of ≥ 15mm, invasion of the lower third of vagina and para-aortic lymph node metastasis were identified as adverse prognostic factors for DFS. The cumulative incidence rate of gastrointestinal and genitourinary toxicity (≥ grade 2) at the 3-year follow-up were 29.6% and 11.6%, respectively. 3D CRT and HDR brachytherapy with concurrent chemotherapy is an effective treatment, with acceptable toxicity for FIGO 2018 stage III cervical cancer in Vietnam..

Modified abdominal radical trachelectomy used to spare fertility during surgery for early-stage cervical cancer: a case report

Cervical cancer is the fourth most common malignant tumor in childbearing-age women. To date, cervical resection and fertility-sparing surgery are the trends in the era of minimally invasive management. However, a proper management remains crucial. Hereby, we endeavor to underscore an uncommon case of early-stage cervical cancer receiving a tailored surgical technique of abdominal radical trachelectomy at our tertiary referral center and review literature. A 33-year-old Vietnamese female patient (E1) was hospitalized for a diagnosis of cervical cancer classified as IB1 stage. The patient was treated with fertility-sparing modified abdominal radical trachelectomy surgery. The postoperative outcome was completely favorable. The patient was sent home after 5 days of hospitalization. In addition, she was monitored without complications. Fertility-preserving treatment could be effectively performed with a modified technique of abdominal radical trachelectomy among young women with early-stage cervical cancer. Interdisciplinary management is potentially necessary for favorable outcome. Further data are required for long-term outcomes of pregnancy, recurrent rate, and the risk of pelvic organ prolapse.