Liya Ding

Ichthyosis uteri complicated by endometrial adenocarcinoma with transitional cell differentiation: A case report

Rationale: Ichthyosis uteri is a rare pathological condition characterized by the replacement of the endometrial lining by stratified squamous epithelium. Yet its occurrence with endometrial adenocarcinoma is very rare. Patient concerns: A 68-year-old woman has been experiencing sporadic, minor vaginal hemorrhages for a few months. The gynecological evaluation revealed a uterine enlargement and imaging demonstrated an irregular mass within the uterus. Diagnosis: Endometrial adenocarcinoma with transitional cell differentiation; ichthyosis uteri with dysplasia. Interventions: Radical hysterectomy with pelvic lymphadenectomy was performed followed by postoperative radiotherapy. Outcomes: Postoperative follow-up at 8 months showed a favorable outcome without signs of recurrence and metastasis. Lessons: Adequate pathological sampling is crucial to identifying the accompanying lesions of ichthyosis uteri. Finding molecular alterations in various pathological morphologies is important to understand the evolution of disease.