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The Association between the Preoperative Prognostic Nutritional Index and the Controlling Nutritional Status Score on Tumor Stage, Chemotherapeutic Response and Overall Survival in Ovarian Cancer

This study aimed to investigate the association between preoperative prognostic nutritional index (PNI) and controlling nutritional status (CONUT) scores on the stage of ovarian cancer (OC), chemotherapeutic response, and overall survival (OS) in patients with OC. The data of the patients who operated due to OC between January 2015 and January 2020 in a tertiary referral hospital were recorded. The patients' basic characteristics, preoperative total cholesterol, albumin, lymphocyte count, tumor markers, disease stage, grade, chemotherapeutic response, OS, and progression-free survival were recorded. The PNI and the CONUT score were calculated. The mean PNI level was considerably higher in the early-stage group than the advanced-stage group (50.02 ± 6.8 vs. 46.3 ± 7.4,

The effect of being diagnosed with human papillomavirus infection on women's sexual lives

AbstractProblemObjective studies that use validated questionnaires are needed to evaluate the changes in the sexual functions of women diagnosed with human papillomavirus (HPV) infection.Method of StudyThe study comprised 80 sexually active women diagnosed with a high‐risk HPV infection. These patients were divided into four groups as follows: group 1, HPV 16/18‐positive and normal cytology; group 2, HPV 16/18‐positive and abnormal cytology; group 3, non‐16/18 HPV‐positive and abnormal cytology; and group 4, non‐16/18 HPV‐positive and normal cytology. The sexual functions and anxiety statuses of the patients were assessed via the Female Sexual Function Index (FSFI) and Beck anxiety inventory (BAI) questionnaires, respectively, at their first clinical visits and then 2 months later.ResultsThere was no statistically significant difference among the study groups in terms of the overall FSFI and domain sub‐scores at either of the visits. Women who tested positive for the high‐risk HPV 16/18 strains had a significantly less sexual desire after being informed about the test results. Those with HPV 16/18 and normal cytology had significantly higher anxiety levels at their second than first visits. The BAI scores of the HPV 16/18‐positive women (normal or abnormal cytology) at the second visit were significantly higher than those of non‐16/18 HPV‐positive women with normal cytology. There was no significant difference between the patients with normal and abnormal cytology results regarding the difference of BAI, overall and domain FSFI sub‐scores at the first and second visits. The desire and lubrication domain scores of the HPV 16/18‐positive patients significantly decreased after the first visit compared with those of the non‐16/18 HPV‐positive patients.ConclusionHPV 16/18 positivity decreases women's total FSFI and desire domain sub‐scores.