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Investigator

Korina Karagianni

Research Assistant in the research project: Identification of novel, differentially edited RNA molecules involved in neurodegenerative disorders pathogenesis · Aristotle University of Thessaloniki, Department of Pharmacy

About

Research Interests

Papers

HPV16 E6 Oncogene Contributes to Cancer Immune Evasion by Regulating PD-L1 Expression through a miR-143/HIF-1a Pathway

Human Papillomaviruses have been associated with the occurrence of cervical cancer, the fourth most common cancer that affects women globally, while 70% of cases are caused by infection with the high-risk types HPV16 and HPV18. The integration of these viruses’ oncogenes E6 and E7 into the host’s genome affects a multitude of cellular functions and alters the expression of molecules. The aim of this study was to investigate how these oncogenes contribute to the expression of immune system control molecules, using cell lines with integrated HPV16 genome, before and after knocking out E6 viral gene using the CRISPR/Cas9 system, delivered with a lentiviral vector. The molecules studied are the T-cell inactivating protein PD-L1, its transcription factor HIF-1a and the latter’s negative regulator, miR-143. According to our results, in the E6 knock out (E6KO) cell lines an increased expression of miR-143 was recorded, while a decrease in the expression of HIF-1a and PD-L1 was exhibited. These findings indicate that E6 protein probably plays a significant role in enabling cervical cancer cells to evade the immune system, while we propose a molecular pathway in cervical cancer, where PD-L1’s expression is regulated by E6 protein through a miR-143/HIF-1a axis.

9Works

1Papers

6Collaborators

Uterine Cervical NeoplasmsBrain DiseasesNeurodegenerative Diseases

Positions

2022–

Research Assistant in the research project: Identification of novel, differentially edited RNA molecules involved in neurodegenerative disorders pathogenesis

Aristotle University of Thessaloniki · Department of Pharmacy

2021–

Research Assistant in Project Award Contract: "PhotoInact - Development and implementation of a photocatalytic system for the inactivation of hazardous medical waste liquids of toxic and/or infectious nature", funded by the Research Project: "Research – Create – Innovate" with code: Τ1ΕΔΚ-02678

Aristotle University of Thessaloniki · Department of Pharmacy

2021–

Research Assistant: Magnetic isolation of microglia, neurons and macrophages from Hu-sCJD mice in P3 conditions

Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria

2021–

Researcher

Centre for Research and Technology Hellas (CERTH)/Institute of Applied Biosciences (INAB) · Internship: In silico analysis in microglial cell line BV2 gene expression and effect of post-transcriptional processing of ADAR mediated RNA Editing following lipopolysaccharide (LPS) treatment

2021–

Research Assistant: Monitoring of the viral load of SARS-CoV-2 in the urban wastewater of Katerini, Pella, Giannitsa, and Rethymno.

Aristotle University of Thessaloniki · Department of Pharmacy

2018–

Internship program: Investigation of Wnt-dependent pathway in intestinal homeostasis and carcinogenesis

Biomedical Sciences Research Center Alexander Fleming · Department of Pharmacy

2017–

Genetic analysis of two genomic regions in AR receptor gene and CYP19 aromatase gene and its association with male infertility

Embryolab Fertility Clinic · Cytogenetic Laboratory

Education

2022

PhD Candidate

Aristotle University of Thessaloniki · Genetics, Development and Molecular Biology

2021

MSc in Applied Genetics and Biodiagnosis

Aristotle University of Thessaloniki · School of Biology, Department of Genetics, Development, and Molecular Biology

2018

BSc in Biology

Aristotle University of Thessaloniki · School of Biology, Department of Genetics, Development, and Molecular Biology

Country

Keywords

RNA EditingNeurodegenerative DisordersRNA biomarkers

Links & IDs

0000-0002-6660-948X