Investigator
Shandong First Medical University
Electron-Shuttling Mechanisms Drive Proximity Labeling to Unveil Tumor Marker Characteristics in Ovarian Cancer from Clinical Samples
In this study, we presented a revolutionary proximity labeling platform, MOF-HRP-Apt, which for the first time integrated electron mediation into the horseradish peroxidase (HRP)-catalyzed proximity labeling system. This novel strategy enabled a single molecular recognition event into multiple covalent labeling events, amplifying spatial signals and enhancing detection sensitivity of the tumor biomarker PTK7. The platform utilized the redox-active iron-based metal-organic framework (MOF) material NH
