Hong Dai

Highly integrated and compact transduction strategy for multidimensional sensing: Near infrared light mediated transmission of optical, electrical and visual signals for ovarian cancer marker assay

Mediating effective signal conversion strategies through intermediate parameters to develop easily integrated smart sensing platforms remains a challenge. Herein, a compact and miniaturized optical, electrical and visual sensor was constructed through reasonably designing and assembling three sub-sensors, which can simultaneously and independently feedback signal changes brought by near-infrared (NIR) light. Concretely, the thermal effect induced by multifunctional V

Self-reduced MXene-Metal interaction electrochemiluminescence support with synergistic electrocatalytic and photothermal effects for the bimodal detection of ovarian cancer biomarkers

Novel two-dimensional MXene with unique optical and electrical properties has become a new focus in the field of sensing. In particular, their metallic conductivity, good biocompatibility and high anchoring ability to biomaterials make them attractive candidates. Despite such remarkable properties, there are certain limitations, such as low oxidative stability. MXene-Metal interactions are an effective strategy to maintain the long-term stability of MXene, while also improving the electrochemical activity and optical properties. Herein, a series of MXene/Ag nanocomposites including Ti

Two-phase dual-signal-readout immunosensing platform based on multifunctional carbon nano-onions for ovarian cancer biomarker detection

In order to detect early tumor markers and gain valuable time for treatment, there is an urgent need to develop a fast, cheap, and ultrasensitive multi-reading sensing platform.

A pressure-colorimetric multimode system with photothermal activated multiple rolling signal amplification for ovarian cancer biomarker detection

Utilizing the photothermal effect to activate enzyme activity, realize signal conversion and amplification show promising prospects in biosensing. Herein, a pressure-colorimetric multi-mode bio-sensor was proposed through the multiple rolling signal amplification strategy of photothermal control. Under NIR light radiation, the Nb

Photothermal-Induced Electrochemical Interfacial Region Regulation Enables Signal Amplification for Dual-Mode Detection of Ovarian Cancer Biomarkers

Detection sensitivity of an electrochemical immunosensor mainly depends on the accessible distance toward the sensing interface; regulating the electrochemical interfacial region thereon is an effective strategy for signal amplification. Herein, a photothermal-regulated sensing interface was designed based on a near-infrared (NIR)-responsive hydrogel probe for ultrasensitive detection of human epididymis protein 4 (HE4). Silver nanoparticle-deposited graphene oxide nanosheet (AgNPs@GO) hybrids as electrochemical signal tags and a photothermal transducer, which were encapsulated in the poly(

Modular and Noncontact Wireless Detection Platform for Ovarian Cancer Markers: Electrochemiluminescent and Photoacoustic Dual-Signal Output Based on Multiresponse Carbon Nano-Onions

An electrochemiluminescent (ECL)-photoacoustic (PA) dual-signal output biosensor based on the modular optimization and wireless nature of a bipolar electrode (BPE) was constructed. To further simplify the detection process, the BPE structure was designed as three separate units: anode ECL collection, cathode catalytic amplification, and intermediate functional sensing units. Specifically, the anode unit was placed with Eosin Yellow, a cheap and effective ECL reagent, and the cathode unit was a laser-induced polyoxometalate-graphene electrode, which was helpful to enhance the anode ECL signal. The intermediate functional sensing unit consisted of a temperature-sensitive conductive film. Further, using a carbon nano-onion nanocomposite with excellent absorption performance in the near-infrared region as a signal tag not only leads to changes in the electrical conductivity of the film through heat transfer and thus affects the ECL signal but also produces a strong PA response. With this design, PA and ECL signals can be output simultaneously. This work not only realizes multiple modularization processes in the design of sensors but also implements the diversification of signal output modes, which will enrich the joint research field of ECL detection technology and other new detection methods.