Gulay Turan

Primary High‐Grade Ovarian Sertoli–Leydig Cell Tumor With Bilateral Adnexal Involvement in a Patient Diagnosed With Peutz–Jeghers Syndrome

Aim Peutz–Jeghers syndrome is a rare genetic disease with an increased risk of gastrointestinal and extragastrointestinal malignancies. Ovarian involvement of Sertoli–Leydig cell tumors is uncommon and even more rare in Peutz–Jeghers syndrome patients. This case report outlines the importance of primary ovarian Sertoli–Leydig cell tumor with bilateral adnexal involvement in a patient diagnosed with Peutz–Jeghers syndrome. Case A 31‐year‐old female patient diagnosed with Peutz–Jeghers syndrome presented to our clinic with pelvic pain. Ultrasound examination revealed solid masses in both adnexa. Laparoscopic fertility‐preserving surgery was performed. Pathology confirmed the diagnosis of poorly differentiated solid ovarian Sertoli–Leydig cell tumor. Staging surgery was performed, and finally, the patient was referred to oncology for chemotherapy. Conclusion This case report outlines the importance of Sertoli–Leydig cell tumors in the differential diagnosis of adnexal masses in patients with Peutz–Jeghers syndrome. Bilateral adnexal involvement is an unusual presentation of Sertoli–Leydig cell tumors. Despite unusual and different presentations, Sertoli–Leydig cell tumors should not be ignored or overlooked in patients with Peutz–Jeghers syndrome.

High-risk HPV genotype distribution and prevalence in cervical swabs from Western Turkey

This retrospective study analyzed HPV-DNA genotyping, cytological, and histopathological findings from cervical swab samples of women aged 18 and older who attended the Gynecology and Obstetrics outpatient clinic at Balıkesir University Health Practice and Research Hospital between October 2022 and March 2024. A total of 1,447 samples from women aged 19-82 were evaluated. High-risk human papillomavirus (HPV) DNA was detected in 144 cases (9.9 %), including 67 single-type and 77 multiple-type infections. The most frequent types were multiple infections without HPV16/18 (22.92 %) and HPV 16 only(18.75 %). The highest positivity rate (18.7 %) was observed in the 35-39 age group. Cytological abnormalities were found in 52 cases (38.30 %), including infection (24.11 %), atypical squamous cells of undetermined significance (ASC-US, 23.07 %), low-grade squamous intraepithelial lesion (LSIL, 5.77 %), atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASCH), high-grade squamous intraepithelial lesion (HSIL), and atypical glandular cells (AGC), each at 1.92. Among HPV-positive patients who underwent biopsy, 6.25 % low-grade squamous intraepithelial neoplasia (LSIL/CIN-I), 4.17 % high-grade squamous intraepithelial neoplasia (HSIL/CIN-II) and 2.78 % HSIL/CIN-III. The results highlight the value of regional HPV genotype surveillance in guiding cervical cancer screening and vaccination strategies.