Investigator

Gürkan Özbey

Adıyaman University, Obstetrics and Gynecology

Gürkan Özbey
Papers(2)
The Effect of Endomet…Photodiagnosis and ph…
Collaborators(4)
Görkem TuncaySenem Arda DüzYılmaz ÇiğremişAbdullah Karaer
Institutions(2)
Adyaman UniversityInonu University

Papers

The Effect of Endometrial Polyp and Myoma Uteri on Fertility-Related Genes in the Endometrium

Abstract Endometrial polyps are hyperplastic overgrowths of the endometrium that contain both glands and stroma. Myoma uteri is the most common benign tumor of the female pelvis and uterus. HOXA10, which is involved during the organogenesis of the uterus in the embryonic period. The aim of this study was to compare the expression levels of infertility-related genes in endometrial tissue obtained from patients with endometrial polyp and myoma uteri and from healthy controls. A total of 36 patients, including 15 women with endometrial polyp and 21 women with myoma uteri, and 23 healthy controls were enrolled in the study. All patients were evaluated using transvaginal ultrasonography. Endometrial tissue samples were collected from the patient and control groups between the 19th and 21st days of the menstrual cycle. Expression levels of the receptivity markers PROK1, PROKR1, PROK2, PROKR2 and HOXA10 genes were determined by RT- PCR. When the patients diagnosed with endometrial polyp and the healthy controls were compared, it was observed statistically significantly that the expression of PROKR1 increased in endometrium tissue of patients with endometrial polyp (p < 0.05). In patients diagnosed with myoma uteri, gene expression levels of endometrial PROKR1 was statistically significant increased and gene expression levels of PROK1, PROKR2, HOXA10 were found to be statistically significantly decreased compared to the controls (p < 0.05). Changes in the endometrial expression of the HOXA10 and prokineticin gene family in patients with myoma uteri and endometrial polyps may explain certain aspects of infertility in these patients.

Photodiagnosis and photodynamic recognition of cervical cancer with SEM and AFM images

So far, the number of patients who die from cancer is quite high. Continuation of early detection research is important to reduce the number of deaths due to cancer. At the time of the literature review, images of the same patients taken from Scanning Electron Microscope (SEM) and Atomic Force Microscope (AFM) for early diagnosis of cervix cancer have not been addressed to date. This article, Photodiagnosis and Photodynamics with SEM and AFM images are valuable in recognizing cervical cancer and starting treatment early. Simultaneous examination of the, Photodiagnosis and Photodynamics with SEM and AFM cervix images of patients will provide us with a far more powerful solution than a one-way solution. Daubechies (db2, db3, db4, and db5), Coiflet (coif5, coif4, coif3, and coif2), Symlet (sym5, sym4, sym3, and sym2), and Biorthogonal (bior1.3, bior2.8, bior1.5, and bior3.3) 16 discrete wavelet transformation families (DWTF) have been applied to AFM and SEM images. One approximate and three detail coefficients have been obtained for each one AFM and SEM cervix images. Homogeneity, contrast, angular second moment, entropy, mean, standard deviation, correlation, cluster prominence, dissimilarity, and cluster shade values have been calculated for each of these one approximate and three detail coefficients. The classification rate found by the averages of the results obtained from the DWTF_JSD, DWTF_HD and DWTF_TD algorithms for AFM and SEM cervix images are 98.29% and 97.10%, respectively. According to these results, it has been determined that SEM images have lower classification rate than AFM images. It has been also observed that the surface roughness of the mAFM images was larger than nAFM and bAFM images. But, it was observed that the volume of particles of the mAFM images has been smaller than nAFM and bAFM images.

9Works
2Papers
4Collaborators
Uterine NeoplasmsEndometrial NeoplasmsUterine Cervical NeoplasmsPhobic Disorders

Positions

2016–

Researcher

Adıyaman University · Obstetrics and Gynecology

Country

TR

Links & IDs
0000-0001-7961-0087

Scopus: 59208513700

Researcher Id: OLR-9626-2025