Investigator

Esra Keles

Assoc Prof · Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi, Gynecologic Oncology

EKEsra Keles
Papers(4)
Endometrial Clear Cel…The persistence of <s…The meaning of high‐r…Comparison of laparos…
Collaborators(10)
Yunus Emre PurutCanan KabacaSerkan AkisMine Guray UzunMurat Levent DereliSerap Topkara SucuBegum Yeni ErdemBurak GirayEvrim Bostanci ErgenEmre Mat
Institutions(5)
Salk Bilimleri Nivers…Sincan Training And R…Marmara UniversityAnkara Etlik Zübeyde …Ko University

Papers

The persistence of HPV type‐specific infections in patients following colposcopic examination: An observational study

AbstractAimHigh‐risk HPV infection is a necessary but not sufficient factor for the development of precancerous lesions and cervical cancer. Beyond mere HPV positivity, the persistence of infection over time plays a crucial role. This study aims to evaluate the clearance and persistence rates of HPV 16 and 18 genotypes.MethodsThe cervical cytology results were reported using the 2014 Bethesda System classification. The cervical cytology samples were analyzed using the Roche Cobas® 4800 HPV tests. Patients with any HPV genotype other than 16 or 18, those with missing data, those who were lost to follow‐up, those who underwent excisional procedures or hysterectomy, and those with high‐grade cervical dysplasia were excluded from this study.ResultsAmong 191 patients (mean age: 41.2 ± 0.6 years, 16.8% postmenopausal), the mean follow‐up was 21.6 ± 0.7 months. No significant differences were found between the clearance and persistence groups in age, follow‐up duration, cervical biopsy, or endocervical curettage results. However, HPV 16 had a higher persistence rate (28.2%), and abnormal cytology was more frequent in the persistence group (p = 0.038).ConclusionsAround 25% of patients had persistent HPV infection. Close monitoring is essential for those with CIN 1 on initial colposcopy, as they may have a higher risk of progressing to high‐grade dysplasia compared to those without dysplasia.

The meaning of high‐risk HPV other than type 16/18 in women with negative cytology: Is it really safe to wait for 1 year?

AbstractBackgroundHuman papillomavirus (HPV) is a primary risk factor for cervical cancer. HPV 16 and 18 are the two most carcinogenic genotypes and have been reported in the majority of cervical cancer. High‐risk HPVs (hrHPVs) other than HPV 16/18 cause approximately a quarter of cervical cancers. We aimed to present the colposcopy‐guided biopsy results of non‐16/18 hrHPV‐infected women with negative cytology.MethodsThis is a retrospective cohort study conducted on 752 patients between the ages of 30‐65 years with non‐16/18 hrHPV and negative cytology undergoing colposcopy‐guided biopsy at a tertiary gynecological cancer center between January‐2016 and January‐2019.ResultsThe mean age of the women was 42.35±9.41 years. Cervical intraepithelial neoplasia (CIN) 2+ lesion was detected in 49 (6.5%) women with negative cytology. The rate of CIN 2+ lesions in women with abnormal cytology was 12.8%. Patients with abnormal cytology had about 2.1 and 2.4 times increased the odds of CIN 2+ lesion in cervical biopsy and endocervical curettage specimens, respectively. CIN 3+ lesion was detected in 20 (2.7%) women with negative cytology. One (0.1%) of the patients with HPV 39 and negative cytology had invasive cervical cancer. The two most common HPV subtypes were HPV 31 and HPV 51.ConclusionsThe risk of cervical preinvasive lesions still can be detected and cannot be completely eliminated among hrHPV other than 16/18‐infected women with negative cytology. Based on the results of this study, referral of non‐16/18 hrHPV‐infected women with negative cytology to colposcopy is supported as a credible and feasible strategy.

86Works
4Papers
12Collaborators
Papillomavirus InfectionsEndometrial NeoplasmsPolycystic Ovary SyndromeAtherosclerosisNeoplasm StagingAdenocarcinoma, Clear CellChoriocarcinoma, Non-gestational

Positions

Assoc Prof

Dr Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi · Gynecologic Oncology

Fellow

Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi · Gynaecological oncology

Education

Hacettepe Üniversitesi Tıp Fakültesi

md

Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi · jinekolojik onkoloji cerrahisi

Country

TR

Links & IDs
0000-0001-8099-8883

Scopus: 57218221785

Researcher Id: ADI-2791-2022