Investigator

Enrica Calura

Ricercatori a tempo determinato · Università di Padova, Dipartimento di Biologia - DiBio

ECEnrica Calura
Papers(1)
The unveiled mosaic o…
Institutions(1)
University Of Padua

Papers

The unveiled mosaic of intra-tumor heterogeneity in ovarian cancer through spatial transcriptomic technologies: A systematic review

Epithelial ovarian cancer is a significant global health issue among women. Diagnosis and treatment pose challenges due to difficulties in predicting patient responses to therapy, primarily stemming from gaps in understanding tumor chemoresistance mechanisms. Recent advancements in transcriptomic technologies like single-cell RNA sequencing and spatial transcriptomics have greatly improved our understanding of ovarian cancer intratumor heterogeneity and tumor microenvironment composition. Spatial transcriptomics, in particular, comprises a plethora of technologies that enable the detection of hundreds of transcriptomes and their spatial distribution within a histological section, facilitating the study of cell types, states, and interactions within the tumor and its microenvironment. Studies investigating the spatial distribution of gene expression in ovarian cancer masses have identified specific features that impact prognosis and therapy outcomes. Emerging evidence suggests that specific spatial patterns of tumor cells and their immune and non-immune microenvironment significantly influence therapy response, as well as the behavior and progression of primary tumors and metastatic sites. The importance of spatially contextualizing ovarian cancer transcriptomes is underscored by these findings, which will advance our understanding and therapeutic approaches for this complex disease.

61Works
1Papers
Colorectal NeoplasmsTumor MicroenvironmentDisease ProgressionTumor-Associated MacrophagesDisease Models, Animal

Positions

2020–

Ricercatori a tempo determinato

Università di Padova · Dipartimento di Biologia - DiBio

2016–

Assegnisti

Università di Padova · Dipartimento di Biologia - DiBio

2018–

Collaboratori

Università di Padova · Dipartimento di Biologia - DiBio

2016–

Collaboratori

Università di Padova · Dipartimento di Scienze Statistiche

2017–

Personale esterno ed autonomi

Università di Padova · Dipartimento di Biologia - DiBio

2016–

Personale esterno ed autonomi

Università di Padova · Dipartimento di Biologia - DiBio

2015–

Borsisti

Università di Padova · Dipartimento di Biologia - DiBio

2015–

Personale esterno ed autonomi

Università di Padova · Dipartimento di Biologia - DiBio

2013–

Assegnisti

Università di Padova · Dipartimento di Biologia - DiBio

Country

IT