Chia-Chun Li

Quality of life and climacteric symptoms in women with endometrial cancer: examining the impact of lower limb lymphedema

Abstract Background Women undergoing treatment for endometrial cancer (EC) often experience climacteric-like symptoms, and some may develop lower limb lymphedema (LLL). LLL can significantly impact women’s quality of life (QoL) and exacerbate climacteric symptoms. In this study, we investigated the prevalence of LLL and explored the differences in climacteric symptoms and QoL between women with and without LLL. Methods A cross-sectional, observational, and comparative study design was employed. Clinical data for 105 women diagnosed with EC were gathered, encompassing demographic details, LLL, climacteric symptoms, and QoL. Instruments used included a demographic-disease survey, the Gynecological Cancer Lymphedema Questionnaire, the Greene Climacteric Scale, and EORTC QLQ-C30 and QLQ-EN24 questionnaires. Descriptive statistics and independent-sample t-tests were utilized for data analysis. Results In this study, 39% of women with EC experienced LLL, with primary symptoms being aching, heaviness, and swelling. Women with LLL also had significantly more severe climacteric symptoms, including anxiety, depression, and vasomotor issues, and they reported poorer physical, role, emotional, cognitive, and social functioning. Additionally, they faced increased fatigue, pain, dyspnea, and more severe specific symptoms like lymphedema, urological and gastrointestinal issues, body image concerns, back/pelvic pain, and hair loss compared to those without LLL. Conclusion The findings of this study enhance understanding of the impact of LLL on climacteric symptoms and QoL in women with EC. Health-care professionals, when advising treatment for EC, should inform women about the likelihood of LLL and assist in early management of its symptoms during and after EC treatment.

Impact of HPV test results and emotional responses on psychosocial burden among Taiwanese women: a cross-sectional study

HPV is a sexually transmitted virus and is the cause of virtually all cervical cancers. Women undergoing HPV testing may experience significant psychosocial burdens, particularly those with a higher negative affect who test positive for the virus. This study investigates the relationships among test results, anxiety/depression, positive affect (PA), negative affect (NA), and psychosocial burden in women receiving their HPV test reports. This was a cross-sectional, observational study design. The data were collected after women received their HPV test reports. A total of 273 women were recruited for this survey study from June 2018 to April 2020 in a medical center in North Taiwan. Data were collected on an author-designed demographic-disease survey, the European Quality of Life Index Version 5D 5-Level-Anxiety/Depression, the International Positive and Negative Affect Schedule-Short Form, and the HPV Impact Profile questionnaire. Data were analyzed by descriptive statistics, independent-sample t-tests, analysis of variance, Pearson correlations, and hierarchical multiple linear regression models. Among 273 women, 171 (62.6%) received HPV-positive results. Women with positive HPV test results reported significantly higher levels of anxiety/depression and NA compared to those with negative results. Additionally, those with positive results experienced greater psychosocial burden and worse sexual impact. Furthermore, age, NA, and PA were significant predictors of psychosocial burden in women who tested positive for HPV. Specifically, younger age, higher NA, and lower PA were significantly associated with increased psychosocial burden in women who received positive test results. Health-care providers should pay attention to the test results and women's emotional status, especially for women who have positive results and exhibit negative moods. To alleviate the psychosocial burden in women who have positive test results and high negative moods, professionals could provide timely HPV information and reserve time for women to ask questions, which could decrease their distress after receiving the report.