Investigator

Bárbara Simas Chagas

Pesquisador Pós-Doc · Universidade Federal de Pernambuco Recife (PE), academic, Antibióticos - Programa de Pós-Graduação em Biotecnologia

BSCBárbara Simas Cha…
Papers(1)
Correlation between h…
Collaborators(3)
Jacinto da Costa Silv…Maria Rosângela Cunha…Paulo José Cunha Mira…
Institutions(1)
Universidade Federal …

Papers

Correlation between human papillomavirus infection and histopathological diagnosis of women in Northeast Brazil

AbstractCervical carcinoma is the fourth leading cause of death among women worldwide. Epidemiological studies claim that human papillomavirus (HPV) infection is a necessary condition for cervical cancer development. Knowledge of the geographic distribution of HPV is important in guiding the introduction of prophylactic vaccines. This study analyzed the prevalence of HPV infection in cervical samples obtained from women with abnormal cervical histopathological diagnosis in Northeast Brazil. The study included an analysis of 211 women whose diagnosis was confirmed for cervical intraepithelial neoplasia type 1 (CIN‐1), cervical intraepithelial neoplasia type 2 (CIN‐2), cervical intraepithelial neoplasia type 3 (CIN‐3), and cancer. The identification of the HPV genotypes was based on the polymerase chain reaction–restriction fragment length polymorphism technique. A total of 42.7% of the samples showed a single HPV infection, while 57.3% showed multiple infections. The most common genotypes detected were HPV‐16, HPV‐18, and HPV‐31. HPV‐16, HPV‐31, HPV‐35, and HPV‐18 were the most common types in CIN‐1 with a single infection. HPV‐16 and HPV‐18 were the most often found in CIN‐2 with a single infection. HPV‐16, HPV‐18, and HPV‐31 were the most detected in CIN‐3 with a single infection. HPV‐16 and HPV‐31 were the most frequent in cancer with a single infection. Multiple infection with HPV‐16 shows a 2.7 times greater risk of CIN‐3 (P = .04). Multiple infections for HPV with HPV‐16 and excluding the HPV18/31 types, were associated with CIN‐3 (P = .01). The results allowed the detection and genotyping of HPV types circulating in the population studied. These findings must be taken into account when devising vaccination strategies against HPV.

20Works
1Papers
3Collaborators

Positions

2019–

Pesquisador Pós-Doc

Universidade Federal de Pernambuco Recife (PE), academic · Antibióticos - Programa de Pós-Graduação em Biotecnologia

2013–

Pesquisador Pós-Doc

Universidade Federal de Pernambuco · Genética

Education

2013

Doutorado em Genética

Universidade Federal de Pernambuco · Genética

2010

Mestrado em Genética

Universidade Federal de Pernambuco Recife (PE), academic · Genética

2007

Graduação em Ciências Biológicas Bacharelado

Universidade Federal de Pernambuco · Genética

Country

BR

Keywords
HPVCâncer cervicalPolimorfismo genéticoDiversidade genéticaAnálise funcional