Birsen Yücel

Is high-density lipoprotein cholesterol a prognostic marker in epithelial ovarian cancer?

SUMMARY OBJECTIVE: The aim of the study was to assess the prognostic potential of high-density lipoprotein cholesterol levels in predicting survival for patients with epithelial ovarian cancer. METHODS: This is a retrospective observational study. The cutoff value for high-density lipoprotein cholesterol was determined through receiver operating characteristic analysis, revealing a value of 45 mg/dL. Patients in Group I had high-density lipoprotein cholesterol values <45 mg/dL, while patients in Group II had high-density lipoprotein cholesterol values ≥45 mg/dL. RESULTS: A total of 219 patients participated in the study, including 78 (36%) in group I and 141 (64%) in group II. high-density lipoprotein cholesterol (HR 0.44, 95%CI 0.27–0.73, p=0.001), age ≥65 (HR 3.02, 95%CI 1.87–4.58, p<0.001), and stage (HR 3.68, 95%CI 1.07–12.67, p=0.038) were identified as independent prognostic factors for overall survival in the multivariate analysis. High-density lipoprotein cholesterol (HR 0.44, 95%CI 0.27–0.72, p=0.001) and N1b (HR 2.32, 95%CI 1.33–4.03, p=0.003) were independent prognostic factors for disease-free survival in the multivariate analysis. CONCLUSIONS: In epithelial ovarian cancer, high-density lipoprotein cholesterol levels were prognostic for both overall survival and disease-free survival.