This study was supported by the National Science and Technology Council in Taiwan (to WWC, grant numbers 110-2320-B-040-026, 111-2320-B-040-007-MY3, and 114-2320-B-040-005-MY3) and Tungs' Taichung MetroHarbor Hospital (to CYC, grant number TTMHH-R1140032). Funding