This study was supported by Noncommunicable Chronic Diseases-National Science and Technology Major Project (2025ZD0544102), Xi'an People's Hospital (Xi'an Fourth Hospital) Research Incubation Fund (LH-15), the National Natural Science Foundation of China (32171465, 82102392), the General Program of Natural Science Foundation of Guangdong Province of China (2021A1515012438), Guangdong Basic and Applied Basic Research Foundation (2020A1515110170), the National Ten Thousand Plan-Young Top Talents of China (80000-41180002), Key Technology R&D Program of Hubei (2025BCB053), Natural Science Foundation of Wuhan (2024040801020369). Funding