This study was funded by a University of Manchester UMRI Interdisciplinary Research Pump-prime Competition. J.C.D. is supported by Cancer Research UK (CRUK) via funding to the Cancer Research UK Manchester Centre (C147/A25254) and their Clinical Academic Training Award (C19941/A28707). J.C. is supported by a Manchester University NHS Foundation Trust Clinical Research Fellowship. E.J.C. is supported by a National Institute for Health and Care Research (NIHR) Advanced Fellowship (NIHR300650). E.J.C., L.Mc.W., R.L.H. and L.M. were supported by the NIHR Manchester Biomedical Research Centre (NIHR203308). Funding