This research was supported by grants from the Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation (DTCRD112-C-04), National Chung Cheng University (112-01426-01) and the National Science and Technology Council, Taiwan (NSTC 110-2314-B-194-002-MY3), and the Research Center for Precision Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan from The Featured Areas Research Center Program within the framework of the Higher Education Sprout Project by the Ministry of Education (MOE) in Taiwan and by Kaohsiung Medical University Research Center Grant (KMU-TC113A01) to M.W.Y.C. Funding