The study was supported by the Science and Technology Commission of Shanghai Municipality (No.22ZR1408800/No.22ZR1409100), National Natural Science Foundation of China (No. 82272970/82472628), Shanghai Municipal Health Bureau (JKKPYC-2024-A02), Shanghai Municipal Health Commission (GWVI-11.2-XD13), and the Fifth Round of Discipline Construction and Talent Cultivation Programs in Shanghai Qingpu District Health and Wellness System (MY2023-5/LX2023-2). Funding