The Role of POLE Mutation in High Risk Endometrial Cancer.

NCT07114653RecruitingOBSERVATIONAL

Summary

The actual role of POLE mutations in high-risk endometrial cancer is undetermined. The main question it aims to answer is: What is the prevalence of POLE mutations in high-risk endometrial cancer case? What is the impact of POLE mutations in real world high-risk endometrial cancer case?

Key Facts

Lead Sponsor

Far Eastern Memorial Hospital

Enrollment

150

Start Date

2025-09-01

Completion Date

2026-12-31

Study Type

OBSERVATIONAL

Official Title

The Role of POLE Mutation in High Risk Endometrial Cancer.

Conditions

Endometrial Neoplasms

Eligibility

Sex

FEMALE

Inclusion Criteria:

* women with high-risk for recurrent endometrial cancer

Exclusion Criteria:

* Nil

Outcome Measures

Primary Outcomes

Prevalence of POLE mutation in high risk endometrial cancer

The prevalence of POLE mutations in women with high-risk for recurrent endometrial cancer

Time frame: 2 years

Secondary Outcomes

The impact of POLE on overall survival

The impact of POLE on overall survival, compared with the other TCGA groups

Time frame: 5 years

Locations

Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital, Banqiao District, Taiwan

Linked Diseases

Endometrial Neoplasms

Endometrial Neoplasms — a type of gynecological cancer.

The Role of POLE Mutation in High Risk Endometrial Cancer.