Anterior Quadratus Lumborum Block as a Component of Multimodal Analgesia for Abdominal Hysterectomies

NCT07046949CompletedNAINTERVENTIONAL

Summary

The main goal of this randomised double-blinded controlled trial is to assess whether adding anterior quadratus lumborum block preoperatively can reduce intraoperative and postoperative opioid consumption, reduce pain after abdominal hysterectomy and improve quality of recovery after anesthesia. The study hypothesis is that anterior QL block bilaterally before the start of a surgery has no impact on perioperative pain relief, can't reduce the need in opioids and will not improve quality of recovery after anesthesia. All patients will undergo general anesthesia with tracheal intubation and mechanical ventilation. Patients will be randomized into two groups. In addition to general anesthesia and multimodal analgesia with parenteral medication II (QL) group will receive also anterior quadratus lumborum block as a regional component.

Key Facts

Lead Sponsor

Yuri Semenyuk Rivne Regional Clinical Hospital

Enrollment

56

Start Date

2025-07-07

Completion Date

2025-12-08

Study Type

INTERVENTIONAL

Official Title

A Randomized Controlled Double-blinded Trial Evaluating the Efficacy of the Anterior Quadratus Lumborum Block as a Component of Multimodal Perioperative Analgesia for Abdominal Hysterectomies

Interventions

ANTERİOR QUADRATUS LUMBORUM BLOCKParenteral administration of analgesicsGeneral Anesthesia (GA)

Conditions

Uterine BleedingUterine NeoplasmsUterine DiseasesUterine Fibroids

Eligibility

Age Range

40 Years – 55 Years

Sex

FEMALE

Inclusion Criteria:

* patients with ASA status I-II
* patients with symptomatic fibroids
* patients scheduled for abdominl hysterectomy

Exclusion Criteria:

* refusal to participate in the study at any of its stages
* ASA class ≥ III
* body mass index \> 40 kg/m2
* use of opiate receptor agonists/antagonists before surgery
* uncontrolled hypertension

Outcome Measures

Primary Outcomes

Pain level after surgery

It will be tested using visual analogue scale (VAS)

Time frame: It will be checked at the folowing stages of the study: 30 minutes (m30) 6 hours (h6), 12 hours (h12), 24 hours (h24), 48 hours (h48) after the end of the surgery.

Requirement of morphine for 24 hours

The investigators will count a dose of morphine administered for patients of both groups postoperatively

Time frame: 24 hours (h24), 48 hours (h48) after the surgery

Intraoperative fentanyl consumption

The investigators will compare fentanyl consumption between two groups, considering that the duration of surgeries differences won't be statistically significant.

Time frame: Intraoperative stage, at the end of the surgery (h0)

Secondary Outcomes

Quality of recovery after anesthesia

The investigators will measure it using QoR-15 questionnaire

Time frame: The investigators will test it in 24 hours after the end of the surgery (h24)

Postoperative nausea

The investigators will define the incidents of nausea in both groups after the surgery

Time frame: At 30 minutes (m30), 6 hours (h6), 12 hours (h12), 24 hours (h24) after the end of the surgery

Perioperative heart rate

The investigators will evaluate heart rate during the surgery and after it will be finished.

Time frame: The investigators will evaluate parameters at intraoperative stage (h0), 30 minutes (m30), 6 hours (h6), 12 hours (h12), 24 hours (h24), 48 hours (h48) after the surgery.

Mean arterial pressure perioperatively

The investigators will evaluate mean arterial pressure during the surgery and after it will be finished.

Time frame: The investigators will evaluate the parameters at intraoperative stage (h0), 30 minutes (m30), 6 hours (h6), 12 hours (h12), 24 hours (h24), 48 hours (h48) after the surgery.

Locations

Yuri Semenyuk Rivne regional cinical hospital, Rivne, Ukraine

Linked Diseases

Uterine Neoplasms

Uterine Neoplasms — a type of gynecological cancer.