RT for Cervical Adenocarcinoma/adenosquamous Carcinoma

NCT06741046Active, Not RecruitingOBSERVATIONAL

Summary

Key Facts

Lead Sponsor

Peking Union Medical College Hospital

Enrollment

400

Start Date

2014-06-01

Completion Date

2025-06-01

Study Type

OBSERVATIONAL

Official Title

Evaluation of the Treatment Response and Prognosis of Cervical Adenocarcinoma/adenosquamous Carcinoma After Radiotherapy: a Retrospective Study

Conditions

Uterine NeoplasmsGenital NeoplasmsFemale

Eligibility

Age Range

18 Years – 80 Years

Sex

FEMALE

Inclusion Criteria:

a) Pathological diagnosis of cervical adenocarcinoma; b) Age 18-80 years old; c) Karnofsky score≥60 points; e) Complete blood count, and comprehensive metabolic panel meet the conditions for CCRT or RT after surgery; f) No metal implants in the body, and can perform MRI examination; g) Willing to participate in this study and provide written informed consent. -

Exclusion Criteria:

1. Patients who have received pelvic radiotherapy before;
2. Patients whose target tumors have been treated before (chemotherapy, immunotherapy, surgical treatment, etc.);
3. Allergy to iodine contrast agent;
4. Participating in other clinical studies that may affect the results of this study (determined by the principal investigator);

f) Serious diseases that may significantly affect compliance with clinical trials, such as unstable heart disease, kidney disease, chronic hepatitis, poorly controlled diabetes, and mental illness that require treatment; g) Other situations that the investigator believes are not suitable for participation in this clinical study.

Outcome Measures

Primary Outcomes

Local control rate

Tumor control rate in the cohort after treatment

Time frame: local control rates at 2 years or 3 years after the initial treatment

Secondary Outcomes

Progress free survival

the time from initial treatment to disease progression or death from any cause.

Time frame: 2 years after initial treatment

Overall survival

The length of time from the start of initial treatment to death or the last followup

Time frame: 2 years after initial treatment

Locations

Peking Union Medical College Hospital, Beijing, China

RT for Cervical Adenocarcinoma/adenosquamous Carcinoma