Oncogenic Role of Engrailed (EN)-2 in Epithelial Ovarian Neoplasms

NCT05553067CompletedOBSERVATIONAL

Summary

Detection of the potential oncogenic role of Engrailed-2 in epithelial ovarian neoplasms, in order to detect biological markers that could be targeted and blocked by new medications.

Key Facts

Lead Sponsor

Sohag University

Enrollment

100

Start Date

2015-01-01

Completion Date

2021-12-31

Study Type

OBSERVATIONAL

Official Title

Oncogenic Role of Engrailed (EN)-2 in Epithelial Ovarian Neoplasms.

Interventions

Immunohistochemical staining of normal and neoplastic ovarian tissues by anti human Engrailed-2 antibody.

Conditions

Ovarian Neoplasms

Eligibility

Age Range

20 Years – 70 Years

Sex

FEMALE

Inclusion Criteria:

* All types of epithelial ovarian neoplasms (benign, borderline and malignant).

Exclusion Criteria:

* Non-epithelial and/ or secondary ovarian tumors.
* Cases with poor clinical data.
* Cases who had history of pre-operative chemotherapy.

Outcome Measures

Primary Outcomes

compare levels of Engrailed-2 expression in different ovarian specimens.

compare levels of immunohistochemical expression of Engrailed-2 in normal and neoplastic ovarian tissues. and correlate Engrailed-2 expression in neoplastic ovarian tissues to patients' ages, tumor phenotype and state of nodal metastasis.

Time frame: December, 2021

Locations

Sohag faculty of medicine, Sohag, Egypt

Linked Diseases

Ovarian Neoplasms

Ovarian Neoplasms — a type of gynecological cancer.

Oncogenic Role of Engrailed (EN)-2 in Epithelial Ovarian Neoplasms