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Retrospective Review on PAEDIATRIC and ADOLESCENT ADNEXAL MASSES

Summary

To review the characteristic, presentation and outcome of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Key Facts

Lead Sponsor

Chinese University of Hong Kong

Enrollment

300

Start Date

2022-08-12

Completion Date

2023-12-31

Study Type

OBSERVATIONAL

Official Title

Retrospective Review on PAEDIATRIC and ADOLESCENT ADNEXAL MASSES

Interventions

No intervention

Conditions

Adnexal Mass

Eligibility

Age Range

1 Day – 21 Years

Sex

FEMALE

Inclusion Criteria:

* girls who presented with adnexal mass
* aged 0-21 years old

Exclusion Criteria:

* Girls older than 21 years old

Outcome Measures

Primary Outcomes

To review the characteristic of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the imaging findings of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the biochemical markers of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the operative record of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the histopathological findings of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the post-operative complications of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the post-operative menstrual symptoms of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

To review the subsequent reproductive outcome of girls presented with adnexal masses to hopefully develop a management algorithm for girls with adnexal masses.

Time frame: Baseline

Locations

The Chinese University of Hong Kong, Hong Kong, Hong Kong

Linked Papers

2020-04-28

A clinical review of ovarian tumors in children and adolescents

To determine the features which predict torsion and the pre-operative indicators of malignancy in cases of ovarian torsion in ovarian tumors (OTs) in children. The medical records of 35 pediatric patients who underwent surgery for OT, except for neonate cases, from 1997 to 2018 at our institution were reviewed retrospectively. The pathological diagnosis was mature teratoma in 17, immature teratoma in 9, yolk sac tumor in 3, and others in 6. The preoperative diagnosis, which was made based on the imaging findings and the serum tumor marker values, matched with the pathological diagnosis in 29/35 (83%). Ovarian torsion occurred in 14/35 (40%). All but one case that presented with torsion had intermittent abdominal pain as the primary symptom. The preoperative white blood cell count was significantly higher in cases where ovary preservation was impossible than where it was possible (p = 0.01) among the cases presenting with torsion. Preoperative imaging findings and the serum tumor marker values enabled us to make an accurate preoperative diagnosis. Patients with intermittent abdominal primary symptoms were more likely to have ovarian torsion than those without such symptoms, and leukocytosis may indicate irreversible ischemic changes in the affected ovary.

Linked Investigators

Hajime Takayasu