Mirvetuximab Soravtansine With Bevacizumab Versus Bevacizumab as Maintenance in Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Peritoneal Cancer
Summary
GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine + Bevacizumab as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression.
Key Facts
Lead Sponsor
AbbVie
Enrollment
520
Start Date
2023-03-15
Completion Date
2027-04-01
Study Type
INTERVENTIONAL
Official Title
Randomized, Multicenter, Open-label, Phase 3 Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FRα-high Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab
Interventions
Conditions
Eligibility
Age Range
18 Years+
Sex
FEMALE
Inclusion Criteria: 1. Adult women \>/=18 years old 2. Confirmed diagnosis of high-grade serous epithelial ovarian, primary peritoneal, or fallopian tube cancer 3. Confirmed high FRα expression by regulatory-agency approved Ventana FOLR1 (FOLR1-2.1) 4. Relapsed disease after frontline (first-line) platinum-based chemotherapy and must be plantinum-sensitive 5. Willing and able to sign the informed consent form (ICF) and adhere to protocol requirements 6. Negative pregnancy test and willing to use highly effective contraceptive method(s) while on study medication and for at least 7 months after the last dose of MIRV and 6 months after the last dose of bevacizumab Exclusion Criteria: 1. Endometrioid, clear cell, mucinous, or sarconmatous histology; mixed tumors containing any of the above or low grade/borderline ovarian tumor 2. More than one line of prior chemotherapy before current/planned triplet therapy 3. PD (progressive disease) while on or following platinum-based therapy 4. Prior or whole-pelvis or wide-field radiotherapy 5. \> Grade 1 peripheral neuropathy 6. History of or concurrent ocular disorders 7. Grade 4 thromboembolic events 8. Not appropriate for bevacizumab treatment 9. Requiring use of folate-containing supplements 10. Prior hypersensitivity to monoclonal antibodies 11. Pregnant or breatfeeding women 12. Received prior MIRV or other FRα-targeting agents 13. Untreated or symptomatic central nervous system metastases 14. History of other malignancy within 3 years prior to signing study consent
Outcome Measures
Primary Outcomes
Assess Progression-free survival (PFS)
Progression-free survival defined as assessed by BICR per RECIST v1.1, defined as the time from date of randomization until BICR-assessed PD or death due to any cause, whichever occurs first
Time frame: Up to 4 years
Secondary Outcomes
Assess Overall survival (OS)
Overall survival (OS), defined as the time from randomization to death
Time frame: Up to 10 years
Assess Safety and tolerability
Adverse events (AEs) will be evaluated according to the NCI CTCAE v5
Time frame: Up to 10 years
Assess time to second disease progression (PFS2)
Second disease progression (PFS2) defined as the time from date of randomization until second disease progression or death, whichever occurs first
Time frame: Up to 10 years
Assess Objective Response Rate (ORR)
Objective response includes best response of complete response (CR) or partial response (PR).
Time frame: Up to 10 years
Assess Duration of response (DOR)
DOR as assessed by the investigator and by BICR in patients who have measurable disease per RECIST v1.1 at randomization and achieved a confirmed response of CR or PR after maintenance therapy"
Time frame: Up to 10 years
Assess Disease-free survival (DFS)
DOR as assessed by the investigator and by BICR in patients who have no measurable disease per RECIST v1.1 at randomization
Time frame: Up to 10 years
CA-125 response
Serum CA-125 response determined using the GCIG criteria
Time frame: Up to 10 years
Patient-reported outcome health-related quality of life (HRQoL) of disease-related symptoms using the NCCN-FACT Ovarian Symptom Index (NFOSI-18) DRS-P (disease-related symptom subscale - physical).
A questionnaire assessing the health of patients with ovarian cancer.
Time frame: Up to 10 years
Locations
Usa Mitchell Cancer Institute /ID# 269661, Mobile, United States
Honorhealth Virginia G. Piper Cancer Care Network - Biltmore /ID# 269987, Phoenix, United States
City of Hope - Orange County Lennar Foundation Cancer Center /ID# 269573, Irvine, United States
Moores Cancer Center at UC San Diego /ID# 269564, La Jolla, United States
Kaiser Permanente - Los Angeles Medical Center /ID# 269541, Los Angeles, United States
University Of California Irvine Medical Center /ID# 269572, Orange, United States
Stanford Women'S Cancer Center /ID# 269552, Palo Alto, United States
Kaiser Permanente - Riverside Medical Center /ID# 269539, Riverside, United States
Kaiser Permanente Zion Medical Center /ID# 269537, San Diego, United States
Kaiser Permanente - San Diego Medical Center /ID# 269540, San Diego, United States
Kaiser Permanente - San Marcos Medical Offices /ID# 269542, San Marcos, United States
Olive View-Ucla Medical Center /ID# 269584, Sylmar, United States
John Muir Health - Walnut Creek Medical Center /ID# 269575, Walnut Creek, United States
Broward General Medical Center /ID# 269577, Fort Lauderdale, United States
Regional Cancer Center /ID# 269558, Fort Myers, United States
Baptist Md Anderson Cancer Center - Jacksonville - Palm Avenue /ID# 269560, Jacksonville, United States
Mount Sinai Medical Center /ID# 269582, Miami, United States
Sarasota Memorial Hospital /ID# 269526, Sarasota, United States
Northside Hospital /ID# 269660, Atlanta, United States
Rush University Medical Center /ID# 269583, Chicago, United States
University of Chicago Medical Center /ID# 269546, Chicago, United States
Indiana University Melvin and Bren Simon Comprehensive Cancer Center /ID# 269110, Indianapolis, United States
St. Vincent Indianapolis Hospital /ID# 269107, Indianapolis, United States
University of Iowa /ID# 269566, Iowa City, United States
The University of Kansas Cancer Center - Westwood /ID# 269106, Westwood, United States
Baptist Health Lexington /ID# 269568, Lexington, United States
University of Kentucky Chandler Medical Center. /ID# 269536, Lexington, United States
Louisiana State University Health Sciences Center - New Orleans /ID# 269559, New Orleans, United States
Ochsner Medical Center - Jefferson Highway /ID# 269530, New Orleans, United States
Maine Medical Center - Scarborough Campus /ID# 269555, Scarborough, United States
Johns Hopkins Hospital /ID# 269579, Baltimore, United States
Sinai Hospital Of Baltimore /ID# 269567, Manchester, United States
GBMC Cancer Center /ID# 269561, Towson, United States
Tufts Medical Center /ID# 269547, Boston, United States
Baystate Medical Center /ID# 269544, Springfield, United States
Corewell Health /ID# 269562, Grand Rapids, United States
Minnesota Oncology - Coon Rapids Clinic /ID# 269550, Coon Rapids, United States
Nebraska Methodist Hospital /ID# 269580, Omaha, United States
The Center Of Hope /ID# 269528, Reno, United States
Dartmouth-Hitchcock Medical Center /ID# 269576, Lebanon, United States
John Theurer Cancer Center /ID# 269109, Hackensack, United States
The Valley Hospital /ID# 269548, Paramus, United States
Holy Name Medical Center /ID# 269543, Teaneck, United States
New York Oncology Hematology - Albany Cancer Center /ID# 269565, Albany, United States
Women'S Cancer Care Associates /ID# 269553, Albany, United States
Northwell Health Center for Advanced Medicine. /ID# 269108, Lake Success, United States
Perlmutter Cancer Center at NYU Langone Hematology Oncology Associates - Mineola /ID# 269534, Mineola, United States
NYU Laura and Isaac Perlmutter Cancer Center /ID# 269556, New York, United States
Icahn School of Medicine at Mount Sinai /ID# 269529, New York, United States
University of North Carolina at Chapel Hill /ID# 269563, Chapel Hill, United States
Duke Cancer Institute /ID# 269557, Durham, United States
University of Cincinnati /ID# 269578, Cincinnati, United States
Jamescare Gynecologic Oncology At Mill Run /ID# 269105, Hilliard, United States
Kettering Medical Center /ID# 269585, Kettering, United States
OU Health - Stephenson Cancer Center /ID# 269525, Oklahoma City, United States
Oklahoma Cancer Specialists and Research Institute /ID# 269527, Tulsa, United States
Willamette Valley Cancer Institute and Research Center /ID# 269988, Eugene, United States
Compass Oncology - Rose Quarter /ID# 270131, Portland, United States
Oregon Health and Science University /ID# 269581, Portland, United States
University Of Pittsburgh Medical Center Magee - Womens Hospital /ID# 269659, Pittsburgh, United States
Allegheny Health Network West Penn Hospital /ID# 269551, Pittsburgh, United States
Asplundh Cancer Pavilion /ID# 269574, Willow Grove, United States
Sanford Cancer Center /ID# 269535, Sioux Falls, United States
West Cancer Center and Research Institute - Germantown /ID# 269569, Germantown, United States
Texas Oncology - Austin Central /ID# 269531, Austin, United States
Texas Oncology - Bedford /ID# 269571, Bedford, United States
Texas Oncology - Methodist Dallas Cancer Center /ID# 269554, Dallas, United States
Texas Oncology - Fort Worth Cancer Center /ID# 269532, Fort Worth, United States
US Oncology Research Investigational Products Center /ID# 278746, Irving, United States
Texas Oncology - San Antonio Medical Center - Research Drive /ID# 269549, San Antonio, United States
University of Virginia Health System /ID# 269545, Charlottesville, United States
Virginia Oncology Associates - Norfolk (Lake Wright) /ID# 269533, Norfolk, United States
VCU Health Adult Outpatient Pavillion /ID# 269570, Richmond, United States
Swedish Cancer Institute /ID# 269538, Seattle, United States
Sanatorio De La Mujer /ID# 269352, Rosario, Argentina
Hospital Italiano de Buenos Aires /ID# 269356, Buenos Aires, Argentina
Hospital Italiano de Córdoba (Sociedad de Beneficencia Hospital Italiano) /ID# 269090, Córdoba, Argentina
Isis Centro Especializado De Luce /ID# 269353, Santa Fe, Argentina
Westmead Hospital /ID# 269362, Westmead, Australia
Gold Coast University Hospital /ID# 269365, Southport, Australia
Ballarat Base Hospital /ID# 269364, Ballarat, Australia
Monash Health - Monash Medical Centre /ID# 269360, Clayton, Australia
Cabrini Hospital Malvern /ID# 269359, Malvern, Australia
Peter MacCallum Cancer Centre /ID# 269361, Melbourne, Australia
Epworth Hospital /ID# 269363, Richmond, Australia
St. John Of God Subiaco Hospital /ID# 269358, Subiaco, Australia
Imelda Ziekenhuis /ID# 269369, Bonheiden, Belgium
Cliniques Universitaires UCL Saint-Luc /ID# 269368, Brussels, Belgium
Grand Hôpital De Charleroi - Notre Dame /ID# 269367, Charleroi, Belgium
AZ Sint-Lucas /ID# 269366, Ghent, Belgium
Universitair Ziekenhuis Leuven /ID# 269370, Leuven, Belgium
AZ-Delta. /ID# 269091, Roeselare, Belgium
UCL Namur University Hospital, Site Sainte-Elisabeth /ID# 269371, Namur, Belgium
Hospital Santa Izabel /ID# 269384, Salvador, Brazil
Catarina Pesquisa Clinica /ID# 269379, Itajaí, Brazil
Beneficência Portuguesa de São Paulo /ID# 269092, São Paulo, Brazil
Hospital Nove De Julho /ID# 269375, São Paulo, Brazil
Complex Oncology Center - Shumen /ID# 269372, Shumen, Bulgaria
Comprehensive Cancer Center /ID# 269373, Vratsa, Bulgaria
Arthur J.E Child Comprehensive Cancer Centre /ID# 269388, Calgary, Canada
Cross Cancer Institute /ID# 269392, Edmonton, Canada
Bc Cancer Agency - Fraser Valley Centre /ID# 269398, Surrey, Canada
BC Cancer - Vancouver /ID# 269394, Vancouver, Canada
Juravinski Cancer Centre - Hamilton Health Sciences /ID# 269396, Hamilton, Canada
Kingston General Hospital /ID# 269397, Kingston, Canada
The Ottawa Hospital - General Campus /ID# 269391, Ottawa, Canada
Princess Margaret Cancer Centre /ID# 269390, Toronto, Canada
Universite de Montreal - Hopital Maisonneuve-Rosemont /ID# 269395, Montreal, Canada
CHUM - Centre hospitalier de l'Universite de Montréal /ID# 269387, Montreal, Canada
McGill University Health Centre - Glen Site. /ID# 269389, Montreal, Canada
CIUSSS Estrie - Sherbrooke University Hospital Center /ID# 269393, Sherbrooke, Canada
The first affiliated hospital of bengbu medical college, Bengbu, China
Capital Medical University (Cmu), Beijing, China
Beijing Cancer Hospital, Beijing, China
Fujian Province Cancer Hospital, Fuzhou, China
The First Affiliated Hospital, Sun-Yat Sen University, Guangzhou, China
Sun Yat-Sen University (Sysu) - Sun Yat-Sen Memorial Hospital, Guangzhou, China
Affiliated Cancer Hospital of Guangxi Medical University, Nanning, China
Harbin Medical University Cancer Hospital, Harbin, China
Henan Cancer Hospital, Zhengzhou, China
The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China
Hubei Cancer Hospital, Wuhan, China
Hunan Province Cancer Hospital, Changsha, China
The First Bethune Hospital Of Jilin University, Changchun, China
Liaoning Cancer Hospital & Institute, Shenyang, China
The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
Qilu Hospital Of Shandong University, Jinan, China
Shandong Cancer Hospital, Jinan, China
LinYi Cancer Hospital, Linyi, China
Fudan University Cancer Hospital /ID# 271025, Shanghai, China
Shanxi Cancer Hospital, Taiyuan, China
West China Second University Hospital, Sichuan University, Chengdu, China
Tianjin Cancer Hospital, Tianjin, China
Cancer Hospital Affliated to Xinjiang Medical University, Ürümqi, China
Yunnan Province Cancer Hospital, Kunming, China
The Affiliated Women'S Hospital Of Zhejiang University, Hangzhou, China
Zhejiang Cancer Hospital, Hangzhou, China
Fakultní Nemocnice Brno - Obilní Trh /ID# 269401, Brno, Czechia
General University Hospital in Prague, Charles University /ID# 269402, Prague, Czechia
Nemocnice Novy Jicin /ID# 269400, Nový Jičín, Czechia
Fakultni nemocnice Ostrava /ID# 269403, Ostrava, Czechia
Hopitaux Universitaires de Strasbourg - Le Nouvel Hopital Civil (NHC) /ID# 269419, Strasbourg, France
Hôpital La Timone /ID# 269421, Marseille, France
Chu Dijon /Id# 269417, Dijon, France
CHU Brest /ID# 269422, Brest, France
Centre Leon Berard /ID# 269418, Lyon, France
Institut Curie /ID# 269420, Paris, France
Klinikum Esslingen /ID# 269435, Esslingen am Neckar, Germany
Universitaetsklinikum Heidelberg /ID# 269438, Heidelberg, Germany
Universitaetsklinikum Erlangen /ID# 269439, Erlangen, Germany
Universitaetsklinikum Giessen /ID# 269432, Giessen, Germany
Onkologische Schwerpunktpraxis Bielefeld /ID# 269440, Bielefeld, Germany
Universitaetsklinikum Bonn /ID# 269434, Bonn, Germany
Klinikum Dortmund Klinikzentrum Mitte /ID# 269441, Dortmund, Germany
Universitaetsmedizin Mainz /ID# 269442, Mainz, Germany
Universitaetsklinikum Carl Gustav Carus Dresden /ID# 269433, Dresden, Germany
Universitaetsklinikum Hamburg-Eppendorf /ID# 269429, Hamburg, Germany
Krankenhaus Jerusalem /ID# 269430, Hamburg, Germany
General Hospital of Athens Alexandra /ID# 269444, Athens, Greece
St. Luke's Hospital S.A. /ID# 269445, Panórama, Greece
Hygeia Hospital /ID# 270132, Athens, Greece
IASO Hospital /ID# 269443, Marousi, Greece
St James Hospital /ID# 269446, Dublin, Ireland
Bon Secours Cork Hospital /ID# 269449, Cork, Ireland
Cork University Hospital /ID# 269451, Cork, Ireland
Beaumont Hospital /ID# 269452, Dublin, Ireland
University Hospital Galway /ID# 269447, Galway, Ireland
Sligo General Hospital /ID# 269448, Sligo, Ireland
Waterford Regional Hospital /ID# 269450, Waterford, Ireland
Edith Wolfson Medical Center /ID# 269461, Holon, Israel
Meir Medical Center /ID# 269454, Kfar Saba, Israel
Rabin Medical Center /ID# 269456, Petah Tikva, Israel
Kaplan Medical Center /ID# 269457, Rehovot, Israel
The Chaim Sheba Medical Center /ID# 269094, Ramat Gan, Israel
Tel Aviv Sourasky Medical Center /ID# 269455, Tel Aviv, Israel
The Lady Davis Carmel Medical Center /ID# 269453, Haifa, Israel
Shaare Zedek Medical Center /ID# 269459, Jerusalem, Israel
Hadassah Medical Center-Hebrew University /ID# 269458, Jerusalem, Israel
ZIV Medical Center /ID# 269460, Safed, Israel
Azienda Ospedaliero Universitaria Careggi /ID# 269465, Florence, Italy
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST - IRCCS /ID# 269474, Meldola, Italy
Ente Ospedaliero Ospedali Galliera /ID# 269472, Genoa, Italy
Ospedale San Martino /ID# 269469, Genoa, Italy
IRCCS Istituto Clinico Humanitas /ID# 269473, Rozzano, Italy
IRCCS Ospedale San Raffaele /ID# 269475, Milan, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori /ID# 269477, Milan, Italy
Casa di Cura San Pio X /ID# 277973, Milan, Italy
Istituto Nazionale Tumori Irccs Fondazione G. Pascale /ID# 269097, Naples, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 269470, Rome, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 269096, Rome, Italy
Ospedale di Mirano - Azienda ULSS 3 /ID# 269462, Mirano, Italy
IRCCS AOU di Bologna Policlinico Sant Orsola Malpighi /ID# 269476, Bologna, Italy
Ospedale Cannizzaro /ID# 269478, Catania, Italy
Alessandro Manzoni Hospital /ID# 269467, Lecco, Italy
Azienda USL Toscana Nord Ovest - Ospedale San Luca /ID# 269095, Lucca, Italy
Azienda Ospedaliero Universitaria Di Parma /ID# 269466, Parma, Italy
Fondazione IRCCS Policlinico San Matteo /ID# 269463, Pavia, Italy
AUSL Piacenza-Ospedale Guglielmo da Saliceto /ID# 269468, Piacenza, Italy
New Hospital of Prato - S. Stefano /ID# 269464, Prato, Italy
AUSL di Reggio Emilia - Arcispedale Santa Maria Nuova /ID# 269471, Reggio Emilia, Italy
Aichi Cancer Center /ID# 274332, Nagoya, Japan
Chiba University Hospital /ID# 274371, Chiba, Japan
The Jikei University Kashiwa Hospital /ID# 274334, Kashiwa, Japan
National Hospital Organization Shikoku Cancer Center /ID# 276078, Matsuyama, Japan
Kurume University Hospital /ID# 274337, Kurume-shi, Japan
Sapporo Medical University Hospital /ID# 274330, Sapporo, Japan
Hokkaido University Hospital /ID# 274331, Sapporo, Japan
Hyogo Cancer Center /ID# 274323, Akashi-shi, Japan
Iwate Medical University Hospital - Yahabacho /ID# 274635, Yahaba, Japan
Kagoshima University Hospital /ID# 276081, Kagoshima, Japan
Tokai University Hospital /ID# 274336, Isehara, Japan
Tohoku University Hospital /ID# 274327, Sendai, Japan
Niigata University Medical & Dental Hospital /ID# 274329, Niigata, Japan
Okayama University Hospital /ID# 274324, Okayama, Japan
Kindai University Hospital /ID# 274335, Sakai-shi, Japan
Osaka Medical And Pharmaceutical University Hospital /ID# 276079, Takatsuki, Japan
Saitama Medical University International Medical Center /ID# 274953, Hidaka, Japan
Shizuoka Cancer Center /ID# 274325, Sunto-gun, Japan
Jichi Medical University Hospital /ID# 274634, Shimotsuke-shi, Japan
National Cancer Center Hospital /ID# 274321, Chuo-Ku, Japan
The Cancer Institute Hospital Of JFCR /ID# 274326, Koto-ku, Japan
Keio University Hospital /ID# 276159, Shinjuku-ku, Japan
The Jikei University Hospital /ID# 276160, Tokyo, Japan
The Medical City /ID# 269493, Pasig, Philippines
East Avenue Medical Center /ID# 269099, Quezon City, Philippines
Cardinal Santos Medical Center /ID# 269100, San Juan City, Philippines
Wielkopolskie Centrum Onkologii /ID# 269494, Poznan, Poland
Jagiellonskie Centrum Innowacji Sp. z o.o. /ID# 269497, Krakow, Poland
Mazowiecki Szpital Wojewodzki im. Sw. Jana Pawla II w Siedlcach Sp. z o.o. /ID# 269500, Siedlce, Poland
Szpitale Pomorskie Sp. z o.o. /ID# 269495, Gdynia, Poland
National Cancer Center /ID# 269481, Goyang-si, South Korea
CHA Bundang Medical Center /ID# 269489, Seongnam, South Korea
Seoul National University Bundang Hospital /ID# 269482, Seongnam-si, South Korea
Keimyung University Dongsan Hospital /ID# 269488, Daegu, South Korea
Korea University Anam Hospital /ID# 269486, Seoul, South Korea
Seoul National University Hospital /ID# 269479, Seoul, South Korea
Yonsei University Health System Severance Hospital /ID# 269483, Seoul, South Korea
Asan Medical Center /ID# 269480, Seoul, South Korea
Gangnam Severance Hospital /ID# 269484, Seoul, South Korea
Samsung Medical Center /ID# 269487, Seoul, South Korea
The Catholic University of Korea, Seoul St. Marys Hospital /ID# 269485, Seoul, South Korea
Korea University Guro Hospital /ID# 269490, Seoul, South Korea
Complejo Hospitalario Universitario A Coruña /ID# 269414, A Coruña, Spain
Institut Català d'Oncologia (ICO) - L'Hospitalet /ID# 269409, L'Hospitalet de Llobregat, Spain
Hospital Universitario Reina Sofia /ID# 270296, Córdoba, Spain
Hospital Universitario Virgen de la Victoria /ID# 269413, Málaga, Spain
Clinica Universidad de Navarra - Pamplona /ID# 269410, Pamplona, Spain
Hospital Universitari Vall d'Hebron /ID# 269406, Barcelona, Spain
Hospital Clinic de Barcelona /ID# 269408, Barcelona, Spain
Hospital Universitari De Girona Doctor Josep Trueta /ID# 269411, Girona, Spain
CLINICA UNIVERSIDAD DE NAVARRA-Madrid /ID# 269405, Madrid, Spain
Hospital Universitario La Paz /ID# 269407, Madrid, Spain
Hospital Clínico Universitario de Valencia /ID# 269412, Valencia, Spain
Baskent Universitesi Adana Uyg. Ve Arast. Merkezi Yuregir Baskent Hastanesi /ID# 270174, Adana, Turkey (Türkiye)
Hacettepe University Faculty of Medicine /ID# 269521, Ankara, Turkey (Türkiye)
Baskent Universitesi Ankara Hastanesi /ID# 269524, Ankara, Turkey (Türkiye)
Cheltenham General Hospital /ID# 269427, Cheltenham, United Kingdom
Guy's Hospital /ID# 269426, London, United Kingdom
The Royal Marsden - Chelsea /ID# 269102, London, United Kingdom
Mount Vernon Hospital /ID# 269423, Northwood, United Kingdom
University Hospital Southampton /ID# 269425, Southampton, United Kingdom
The Royal Marsden - Sutton /ID# 269103, Sutton, United Kingdom
The Christie /ID# 269428, Manchester, United Kingdom
Singleton Hospital /ID# 269424, Swansea, United Kingdom