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Spectroscopy in Ovarian Cancer

NCT04817449CompletedOBSERVATIONAL

Summary

Ovarian cancer is the eighth most common cause of cancer death in the world. Advanced stage at diagnosis is associated with lower survival rates, thus early detection appears to have an important role. Raman Spectroscopy is a non-invasive technique that uses the interaction of light to identify the composition of the sample tested. The aim of the project is to explore the use of spectroscopic techniques in the detection of ovarian cancer. There are two different assessments within the project: 1. Identify ovarian cancer in blood - Raman spectroscopic analysis will be performed on blood plasma taken from patients with suspected ovarian cancer. 2. Detect active cancer within post chemotherapy fibrotic tissue - Ex vivo Raman spectroscopic analysis of peritoneal, omental or ovarian tissues collected from patients undergoing surgical treatment for ovarian cancer. The results of the spectroscopy will be correlated to clinical outcome and histological diagnosis respectively.

Key Facts

Lead Sponsor

University of Exeter

Enrollment

160

Start Date

2021-06-28

Completion Date

2023-10-01

Study Type

OBSERVATIONAL

Official Title

Molecular Spectroscopy in Identification and Assessment of Ovarian Cancer

Conditions

Ovarian CancerOvarian NeoplasmsOvary CystOvary Disease

Eligibility

Age Range

18 Years+

Sex

FEMALE

Inclusion Criteria:

* Female
* Symptoms suggestive of ovarian cancer
* Patients undergoing treatment of Ovarian Cancer

Exclusion Criteria:

* Less than 18 years of age
* Unable to consent to the study due to communication difficulties
* Unable to consent to the study due to lack of capacity

Outcome Measures

Primary Outcomes

Ascertain the diagnostic performance of vibrational spectroscopy for detection of Ovarian Cancer

Biomarkers for ovarian cancer will be identified by analysing Raman spectral data of plasma samples taken from patient with ovarian cancer symptoms. Clinical outcome of cancer/no cancer will be used to correlate the results.

Time frame: 2 years

Ascertain the discriminatory ability of vibrational spectroscopy to differentiate between normal, fibrotic and cancerous tissue

Samples taken from post chemotherapy patients will be analysed to identify the spectral signature of ovarian cancer in chemotherapy exposed tissue.

Time frame: 2 years

Secondary Outcomes

Performance of vibrational spectroscopy in chemotherapy response prediction

Plasma samples after 1st cycle of chemotherapy will be analysed to evaluate for changes in biomarkers after chemotherapy treatment.

Time frame: 2 years

Performance of vibrational spectroscopy in recurrence prediction

Plasma samples after recurrence of cancer will be analysed and compared to initial spectral signature at diagnosis

Time frame: 2 years

Locations

University Hospitals Bristol and Weston NHS Trust, Bristol, United Kingdom

Linked Diseases

Ovarian Neoplasms

Ovarian Neoplasms — a type of gynecological cancer.