The Biomarker Analysis in Locally Advanced Cervical Cancer

NCT03635216UNKNOWNOBSERVATIONAL

Summary

Sonic hedgehog (Shh) signaling, including Gli1, is critical to treatment resistance. For optimizing cervical cancer treatment, the pathological prognostic factors determine whether to administer adjuvant therapy. However, the majority of clinical results was from squamous cell carcinoma, rendering conclusions for adenocarcinoma less convincing. We aimed to examine the role of Shh signaling in long-term clinical outcomes of cervical adenocarcinoma after receiving major surgery.

Key Facts

Lead Sponsor

Mackay Memorial Hospital

Enrollment

62

Start Date

2018-05-21

Completion Date

2018-05-21

Study Type

OBSERVATIONAL

Official Title

The Biomarker Analysis in Locally Advanced Cervical Cancer

Conditions

Uterine Cervical Neoplasms

Eligibility

Age Range

20 Years – 80 Years

Sex

FEMALE

Inclusion Criteria:

* cervical cancer patients
* performance status Eastern Cooperative Oncology Group 0-1 (ECOG 0-1)

Exclusion Criteria:

* non-other cancer previously

Outcome Measures

Primary Outcomes

Shh, Ptch-1, Smo and Gli1

Sonic hedgehog (Shh) signaling, including Gli1, is critical to treatment resistance. to examine the role of Shh signaling in long-term clinical outcomes of cervical adenocarcinoma after receiving major surgery

Time frame: 1987-2002

Secondary Outcomes

overall survival

The length of time from either the date of diagnosis or the start of treatment for cervical cancer

Time frame: 1987-2002

progression free survival

the length of time during and after the treatment of cervical cancer

Time frame: 1987-2002

local recurrence

cervical cancer that has recurred at or near the same place as the original tumor

Time frame: 1987-2002

Locations

Mackay Memorial Hospital, Taipei, Taiwan

Linked Diseases

Uterine Cervical Neoplasms

Uterine Cervical Neoplasms — a type of gynecological cancer.

The Biomarker Analysis in Locally Advanced Cervical Cancer