Can Staging Magnetic Resonance Imaging (MRI) Features Prognosticate Patients Presenting With Endometrial Cancer?

NCT03543215UNKNOWNOBSERVATIONAL

Summary

Aim: Assess the value of MRI features in predicting prognosis in patients with endometrial cancer This study will examine the MRI features of women with confirmed endometrial cancer to see if textural features can prognosticate patients.

Key Facts

Lead Sponsor

Imperial College London

Enrollment

500

Start Date

2017-07-13

Completion Date

2021-12-10

Study Type

OBSERVATIONAL

Official Title

Can Staging Magnetic Resonance Imaging (MRI) Features Prognosticate Patients Presenting With Endometrial Cancer?

Interventions

Radiomics: Analysis of textural features of imaging (MRI and Ultrasound)

Conditions

Endometrial CancerEndometrial Neoplasms

Eligibility

Age Range

18 Years+

Sex

FEMALE

Inclusion Criteria:

* All women presenting with a confirmed diagnosis of endometrial cancer
* Reviewed at the Specialist Gynaecology Oncology MDT
* Have MR Imaging and Hysterectomy specimens available for review.

Exclusion criteria:

* Anyone lacking capacity.
* \<18years old.
* Pregnant.
* No MR Imaging available for review -- No pathology specimen available for review

Outcome Measures

Primary Outcomes

To assess the value of MRI features in predicting prognosis in patients with endometrial cancer using progression free survival (PFS) and overall survival (OS) as end points

Assess features of pelvic MRIs (including (i) tumour image intensity, (II) shape, (III) texture and (IV) multiscale wavelet) and create a mathematical algorithm to predict prognostic outcome (5 year survival).

Time frame: 8 years (3 year data collection and 5 year follow up).

Secondary Outcomes

Assess the correlation between imaging features and histopathological features.

Assess textural features of pelvic MRI in conjunction with histopathology (type of tumour, grade LVSI, 'aggressiveness' of cancer

Time frame: 3 years

Locations

Queen Charlotte and Hammersmith Hospital, London, United Kingdom

Linked Investigators

Andrea G Rockall