Summary
The purposes of this study are: (1) to develop magnetic resonance (MR) imaging and spectroscopy as surrogate biomarkers for altered cancer metabolism in cervical cancer; (2) to understand the function of human papillomavirus (HPV) infection and autophagy (a cellular catabolic degradation response to stress) in the metabolic alterations in cervical cancer.
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Inclusion Criteria: * be able to give informed consent. * female patients between 20 and 80 years of age. * biopsy proven newly diagnosed cervical cancer clinical stage International Federation of Gynecology and Obstetrics (FIGO) Ib and above. * patients must be willing to undergo standard treatment such as surgery or chemo-radiation therapy. Exclusion Criteria: * patients who are judged to be noncompliant to treatment or not accessible for follow up. * patients with contraindications to magnetic resonance imaging (MRI) scanning, such as claustrophobia, cardiac pacemaker, metal implants in field of view, or unable to cooperate for MRI study due to mental status.