MRI (Including Spectroscopy and Fat-Saturations and Diffusion-Weighted Imaging) in Cervical Cancer

Summary

To detect differences in MR spectroscopy, diffusion weighted MR, diffusion tensor imaging (DTI) or dynamic contrast enhancement (DCE) MR imaging between primary cervical tumors and normal cervical tissue.

Key Facts

Interventions

Conditions

Eligibility

Inclusion Criteria:

* Patients must have biopsy-proven newly diagnosed squamous cell cervical cancer (FIGO clinical stages IB2-IVA).
* Patients must be ≥ 18 years of age.
* Patients must be able to receive standard radiation therapy (external beam radiation and brachytherapy) with or without chemotherapy.
* Patients with distant metastatic disease are eligible provided the estimated survival of the patient is at least one year.
* Patients must be scheduled to undergo or have already undergone FDG-PET/CT imaging for clinical staging cervical cancer at Barnes-Jewish Hospital Clinical PET facility on the Siemens Biograph 40 True Point Tomograph Scanner or elsewhere in the WUSM Nuclear Medicine department using the quality controls instituted by Nuclear Medicine.
* Patients must be able to give informed consent.

Exclusion Criteria:

* Patients with another known active malignancy.
* Patients who have received treatment for any malignancy (with the exception of non-melanoma skin cancer) in the past 5 years.
* Pregnant or breastfeeding patients.
* Patients whose tumors are not FDG avid on baseline standard of care FDG-PET/CT imaging.
* Patients with contraindications to MRI scanning.

Outcome Measures

Locations

Linked Diseases